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Advances in Cancer Research: Vol 85
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Advances in Cancer Research: Vol 85 Hardcover - 2002

by Vande Woude, George F. (Editor)/ Klein, George (Editor)

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Academic Pr, 2002. Hardcover. New. 1st edition. 256 pages. 9.00x6.00x0.75 inches.
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First line

Although it is presently not known exactly why loss of the VHL gene results in tumorigenesis, one of the first clues to the function of the VHL protein came with the discovery that clear cell renal carcinoma cells lacking a functional VHL gene misregulate and constitutively express hypoxia-inducible genes like glucose transporter-1 (GLUT1), vascular endothelial growth factor (VEGF), and transforming growth factor (TGF) (Gnarra et al., 1996; Iliopoulos et al., 1996; Siemeister et al., 1996; Knebelmann et al., 1998; de Paulsen et al., 2001).

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