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Advances in Cancer Research: Vol 85 Hardcover - 2002
by Vande Woude, George F. (Editor)/ Klein, George (Editor)
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- Hardcover
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Details
- Title Advances in Cancer Research: Vol 85
- Author Vande Woude, George F. (Editor)/ Klein, George (Editor)
- Binding Hardcover
- Edition U. S. EDITION
- Condition New
- Pages 251
- Volumes 1
- Language ENG
- Publisher Academic Pr, USA
- Date 2002
- Bookseller's Inventory # __0120066858
- ISBN 9780120066858 / 0120066858
- Weight 1.1 lbs (0.50 kg)
- Dimensions 9.22 x 6.38 x 0.65 in (23.42 x 16.21 x 1.65 cm)
- Dewey Decimal Code 616.994
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First line
Although it is presently not known exactly why loss of the VHL gene results in tumorigenesis, one of the first clues to the function of the VHL protein came with the discovery that clear cell renal carcinoma cells lacking a functional VHL gene misregulate and constitutively express hypoxia-inducible genes like glucose transporter-1 (GLUT1), vascular endothelial growth factor (VEGF), and transforming growth factor (TGF) (Gnarra et al., 1996; Iliopoulos et al., 1996; Siemeister et al., 1996; Knebelmann et al., 1998; de Paulsen et al., 2001).