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Risk Assessment with Time to Event Models
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Risk Assessment with Time to Event Models Hardcover - 2001

by Crane, Mark (Edited by)/ Newman, Michael C. (Edited by)/ Chapman, Peter F. (Edited by)/ Fenlon, John S. (Edited by)

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Lewis Pub, 2001. Hardcover. New. 1st edition. 192 pages. 9.25x6.25x0.50 inches.
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From the publisher

How can environmental regulators use information on 48-hour toxicity tests to predict the effects of a few minutes of pollution? Or, at the other extreme, what is the relevance of 96-hour toxicity data for organisms that may have been exposed to a pollutant for six months or more? Time to event methods are the key to answering these types of questions.

Risk Assessment with Time to Event Models is the first comprehensive treatment of these methods in the context of ecological risk assessment. Leading experts from industry, academia, and government regulatory agencies explain how these methods can be used to extract more useful information from laboratory data than is present in simple summary statistics like 48-h LC50.

The book offers a clear introduction to the field through several approaches, from the introductory to the more mathematical. Risk Assessment with Time to Event Models demonstrates the relevance of time in the analysis and reporting of toxicity data through the use of practical examples from the field of environmental toxicology. It also incorporates helpful analogies from other disciplines that commonly use time to event modeling.

First line

Conventional effects metrics, e.g., LC/EC50 and NOEC, focus on exposure intensity while holding duration of exposure constant; exposure intensity is estimated precisely but exposure duration is grossly fixed as acute or chronic.

About the author

Mark Crane, Michael C. Newman, Peter F. Chapman, John S. Fenlon