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Risk Assessment with Time to Event Models

Risk Assessment with Time to Event Models Hardback - 2001

by Mark Crane

  • New
  • Hardcover

Description

Hardback. New. Presents a comprehensive treatment to event methodology. This book explains how these methods can be used to extract more useful information from laboratory data than can be gained from the use of simple summary statistics. It offers an introduction to the field through several approaches, from the introductory to the more mathematical.
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Details

  • Title Risk Assessment with Time to Event Models
  • Author Mark Crane
  • Binding Hardback
  • Edition This is the Firs
  • Condition New
  • Pages 188
  • Volumes 1
  • Language ENG
  • Publisher CRC Press
  • Date 2001-12-04
  • Illustrated Yes
  • Features Bibliography, Illustrated, Index
  • Bookseller's Inventory # A9781566705820
  • ISBN 9781566705820 / 1566705827
  • Weight 0.89 lbs (0.40 kg)
  • Dimensions 9.72 x 6.24 x 0.64 in (24.69 x 15.85 x 1.63 cm)
  • Library of Congress subjects Environmental risk assessment - Methodology
  • Library of Congress Catalog Number 2001038737
  • Dewey Decimal Code 363.702

From the publisher

How can environmental regulators use information on 48-hour toxicity tests to predict the effects of a few minutes of pollution? Or, at the other extreme, what is the relevance of 96-hour toxicity data for organisms that may have been exposed to a pollutant for six months or more? Time to event methods are the key to answering these types of questions.

Risk Assessment with Time to Event Models is the first comprehensive treatment of these methods in the context of ecological risk assessment. Leading experts from industry, academia, and government regulatory agencies explain how these methods can be used to extract more useful information from laboratory data than is present in simple summary statistics like 48-h LC50.

The book offers a clear introduction to the field through several approaches, from the introductory to the more mathematical. Risk Assessment with Time to Event Models demonstrates the relevance of time in the analysis and reporting of toxicity data through the use of practical examples from the field of environmental toxicology. It also incorporates helpful analogies from other disciplines that commonly use time to event modeling.

First line

Conventional effects metrics, e.g., LC/EC50 and NOEC, focus on exposure intensity while holding duration of exposure constant; exposure intensity is estimated precisely but exposure duration is grossly fixed as acute or chronic.

About the author

Mark Crane, Michael C. Newman, Peter F. Chapman, John S. Fenlon