54 offprints, reprints Hermann J. Muller Nobel Prize winner by Muller, Hermann J. Herman J. Muller

Various, 1914-1952. Pamphlet. Collectible; Very Good. Prompt shipment, with tracking. we ship in CLEAN SECURE NEW boxes A full list of offprints in this offering is available. Among the ones on offer: Advances in Radiation Mutogenesis Through Studies on Drosophila (1959); Isolating Mechanisms, Evolution and Temperature (1942); The Bearing of the Selection Experiments of Castle and Phillips on the Variability of Genes (1914); The Origination of Chromatin Deficiencies as Minute Deletions Subject to Insertion Elsewhere (1935). Several of the offprints have compliments of the author in stamp or hand, a few have the ownership signature of Sewall Wright, stamps of E. M. East and Karl Sax and others. Most are in very good condition, a few have small nicks and tiny chips to edges. List of Works by H.J. Muller 28 pages listing 383 items dates, titles, and where published. putting together a collection such as this would be impossible these days one at a time, as they rarely appear in dealer catalogs or online outside of this collection. . Provenance: William B. Provine At Columbia, Muller and his collaborator and longtime friend Edgar Altenburg continued the investigation of lethal mutations. The primary method for detecting such mutations was to measure the sex ratios of the offspring of female flies. They predicted the ratio would vary from 1:1 due to recessive mutations on the X chromosome, which would be expressed only in males (which lacked the functional allele on a second X chromosome). Muller found a strong temperature dependence in mutation rate, leading him to believe that spontaneous mutation was the dominant mode (and to initially discount the role of external factors such as ionizing radiation or chemical agents). In 1920, Muller and Altenburg coauthored a seminal paper in Genetics on "modifier genes" that determine the size of mutant Drosophila wings. In 1919, Muller made the important discovery of a mutant (later found to be a chromosomal inversion) that appeared to suppress crossing over, which opened up new avenues in mutation-rate studies. However, his appointment at Columbia was not continued; he accepted an offer from the University of Texas and left Columbia after the summer of 1920.[ wikipedia