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Anticancer Drug & Carbon Nanotubes: Formulation Development of Methotrexate loaded Multi walled Carbon Nanotubes

Anticancer Drug & Carbon Nanotubes: Formulation Development of Methotrexate loaded Multi walled Carbon Nanotubes

Anticancer Drug & Carbon Nanotubes: Formulation Development of Methotrexate
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Anticancer Drug & Carbon Nanotubes: Formulation Development of Methotrexate loaded Multi walled Carbon Nanotubes Paperback - 2012

by Modi, Chetna

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paperback. Good. Access codes and supplements are not guaranteed with used items. May be an ex-library book.
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  • Title Anticancer Drug & Carbon Nanotubes: Formulation Development of Methotrexate loaded Multi walled Carbon Nanotubes
  • Author Modi, Chetna
  • Binding Paperback
  • Condition Used - Good
  • Pages 136
  • Volumes 1
  • Language ENG
  • Publisher LAP Lambert Academic Publishing
  • Publication date 2012-07
  • Bookseller's Inventory # 365919350X.G
  • ISBN 9783659193507 / 365919350X
  • Weight 0.46 lbs (0.21 kg)
  • Dimensions 9 x 6 x 0.32 in (22.86 x 15.24 x 0.81 cm)
  • Category Medical / Nursing
  • Quantity available 1

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Reader reviews for Anticancer Drug & Carbon Nanotubes: Formulation Development of Methotrexate loaded Multi walled Carbon Nanotubes

From the publisher

Several delivery systems are developed to target methotrexate to cancer tissues with limited success due to low drug loading, size control, toxicity, and scale up and also the cost of formulation. Off late, carbon nanotubes have been projected as a promising carrier for many drugs including anticancer agents. The present work is an attempt to investigate the potentialities of multi-walled carbon nanotubes (MWCNT) as a arrier for targeting methotrexate to cancer tissues. MWCNTs were functionalized using DSPE-mPEG 2000 and was then reacted with methotrexate (MTX) to produce MWCNT-mPEG-MTX conjugate. The conjugate was characterized for particle size, loading efficiency, morphology & rate of drug release. The result indicated that about 2.26 mg of Methotrexate per mg of MWCNTs were loaded with 56.5% entrapment efficiency. Particle size of the MWCNT conjugate was found to be less than 200nm with polydispersity index of 0.286 post lyophilization of the product. The MWCNT conjugate was found to release the drug faster in acidic medium than at neutral pH. However, in both neutral and acidic media, the release was continuous over the period of 48 hours.
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