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Anticancer Drug & Carbon Nanotubes
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Anticancer Drug & Carbon Nanotubes Paperback - 2012

by Chetna Modi; R. S. Murthy; Dipak Modi

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Several delivery systems are developed to target methotrexate to cancer tissues with limited success due to low drug loading, size control, toxicity, and scale up and also the cost of formulation. Off late, carbon nanotubes have been projected as a promising carrier for many drugs including anticancer agents. The present work is an attempt to investigate the potentialities of multi-walled carbon nanotubes (MWCNT) as a arrier for targeting methotrexate to cancer tissues. MWCNTs were functionalized using DSPE-mPEG 2000 and was then reacted with methotrexate (MTX) to produce MWCNT-mPEG-MTX conjugate. The conjugate was characterized for particle size, loading efficiency, morphology & rate of drug release. The result indicated that about 2.26 mg of Methotrexate per mg of MWCNTs were loaded with 56.5% entrapment efficiency. Particle size of the MWCNT conjugate was found to be less than 200nm with polydispersity index of 0.286 post lyophilization of the product. The MWCNT conjugate was found to release the drug faster in acidic medium than at neutral pH. However, in both neutral and acidic media, the release was continuous over the period of 48 hours.

Details

  • Title Anticancer Drug & Carbon Nanotubes
  • Author Chetna Modi; R. S. Murthy; Dipak Modi
  • Binding Paperback
  • Pages 136
  • Volumes 1
  • Language ENG
  • Publisher LAP Lambert Academic Publishing
  • Publication date 2012-07
  • ISBN 9783659193507 / 365919350X
  • Weight 0.46 lbs (0.21 kg)
  • Dimensions 9 x 6 x 0.32 in (22.86 x 15.24 x 0.81 cm)
  • Category Medical / Nursing

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Anticancer Drug & Carbon Nanotubes: Formulation Development of Methotrexate loaded Multi...
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Anticancer Drug & Carbon Nanotubes: Formulation Development of Methotrexate loaded Multi walled Carbon Nanotubes

by Modi, Chetna

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ISBN 10 / ISBN 13
9783659193507 / 365919350X
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LAP Lambert Academic Publishing, 2012-07-25. paperback. New. 5.91x0.31x8.66. Buy with confidence. Excellent Customer Service & Return policy.
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NZ$164.90
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Anticancer Drug & Carbon Nanotubes: Formulation Development of Methotrexate loaded Multi walled...
Stock photo: cover may vary

Anticancer Drug & Carbon Nanotubes: Formulation Development of Methotrexate loaded Multi walled Carbon Nanotubes

by Modi, Chetna

  • Used
  • Good
  • Paperback
Condition
Good
Binding
Paperback
ISBN 10 / ISBN 13
9783659193507 / 365919350X
Quantity available
1
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Free Delivery to USA

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Description:
paperback. Good. Access codes and supplements are not guaranteed with used items. May be an ex-library book.
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Item price
NZ$195.60
Free Delivery to USA